Taking a series of documented data revealed by Antonio Sartori as the point of departure, the present study deals with a decorative scheme executed by the painter Domenico Bottazzo at the Scuola del Santo in Padua between 1508 and 1520. The artist was responsible for executing a painted decoration in monochrome ornaments of the ceiling made up of 144 panels, and decorating the lesenes and ornamental strips dividing pictorial compositions painted on walls. A decorative scheme that has never been studied before, it is exceptional because of its perfect state of preservation, the inventiveness of numerous solutions employed as well as the high level of workmanship. The painter knew how to attain equilibrium between various artistic inspirations drawn from the painting of Andrea Mantegna and Bernardino da Parenzo, as well as from sculpture, with references especially to Tullio and Antonio Lombardo, Andrea Riccio and Severo da Ravenna.