The essay presents what has been accomplished, museologically and museographically, in the period 1998–2018 at the Civic Museum of Vicenza. These years saw the complete renovation of Palazzo Chiericati, an architectural masterpiece by Andrea Palladio and a building included in the list of UNESCO World Heritage Sites. The census of its collections and the reflection carried out around their reorganization, in addition to the cultural policy of the Museum, started with the publication of scientific catalogs and the review of didactic paths, and continued with the opening of the museum to the public, and the development of exhibition projects elsewhere in Italy and abroad.