The article casts new light on the dating and discusses the style of a drawing of Saint Roch by Lorenzo Lotto (formerly in the Bestegui collection Paris, now in the Louvre, Department of Graphic Art). The work has been reconsidered by confronting it with Lotto's anti-plague series (1531—1549/50). A new analysis of the style and technique of the drawing, in connection with some of Lotto's painted works, allows to propose a new dating of the drawing — before 1531.